Liquid Chromatography Mass Spectrometry

Liquid chromatography mass spectrometry (LCMS) separates out the individual components in an aqueous mixture which are detected by a sensitive time of flight mass spectrometer.

Liquid chromatography mass spectrometry (LCMS) separates components of a mixture by using a liquid mobile phase and various stationary phases (a column). The components will separate in the column as each component will have a different affinity for the stationary and mobile phase, therefore, the components will reach the detector at different times. A time of flight mass spectrometer can determine the mass of the components to low concentration levels.

 

The major applications of LCMS are (but not limited to) toxicology for forensic science, metabolites in fluid for biomedical applications, drug development in pharmaceutical sciences and the analysis of environmental samples for pesticides.

Equipment

  • LC-MS: Agilent 1260 Infinity II HPLC coupled to iFunnel 6550 QToF with ESI

Staff

Photo of Liquid Chromatography Mass Spectrometry

Location

Opening Times

The instrument must be booked in advance

Usual access times are Mon – Friday 9am – 4.30pm

 

Note – automated analysis overnight is possible

Hub

Science Hub

for Career Prospects

Whatuni Student Choice Awards 2025

for Facilities

Whatuni Student Choice Awards 2023

for Social Inclusion

The Times and The Sunday Times Good University Guide 2023

of Research Impact is ‘Outstanding’ or ‘Very Considerable’

Research Excellence Framework 2021

of Research is “Internationally Excellent” or “World Leading”

Research Excellence Framework 2021

Four Star Rating

QS Star Ratings 2021